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  "Title": "Pedigree-Based Heritability Estimation for Family Cohort Studies",
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  "Authors@R": "c(\nperson(\"Lucas\", \"França\",\nemail = \"lucas.franca@northumbria.ac.uk\",\nrole = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0003-0853-1319\")),\nperson(\"Mario\", \"Leocadio-Miguel\",\nemail = \"mario.miguel@northumbria.ac.uk\",\nrole = \"aut\",\ncomment = c(ORCID = \"0000-0002-7248-3529\"))\n)",
  "Description": "Provides profile-likelihood variance-components estimation\nof narrow-sense heritability (h2) for quantitative traits in\nfamily cohort studies. Additive genetic relationship matrices\nare built from pedigrees via 'kinship2'. Phenotypes are\ninverse-normal transformed internally. Likelihood-ratio tests\nuse a one-sided chi-squared boundary correction equivalent to\nSOLAR Eclipse. Ninety-five percent confidence intervals are\nderived from the profile likelihood rather than Wald\napproximations. Batch estimation over many traits returns tidy\ndata frames ready for downstream visualisation (forest plots,\nheatmaps).",
  "License": "MIT + file LICENSE",
  "URL": "https://r-itable.circadia-lab.uk,\nhttps://github.com/circadia-bio/R-itable",
  "BugReports": "https://github.com/circadia-bio/R-itable/issues",
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  "Repository": "https://circadia-bio.r-universe.dev",
  "Date/Publication": "2026-06-08 11:41:14 UTC",
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    "User": "root"
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  "Author": "Lucas França [aut, cre] (ORCID:\n<https://orcid.org/0000-0003-0853-1319>),\nMario Leocadio-Miguel [aut] (ORCID:\n<https://orcid.org/0000-0002-7248-3529>)",
  "Maintainer": "Lucas França <lucas.franca@northumbria.ac.uk>",
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  "_published": "2026-07-02T00:45:18.564Z",
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    "description": "Immigrant, physicist, neuroscientist, open source and data science enthusiast.",
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