Overview | 1. Build the GRM | 2. Estimate heritability for a single trait | 3. Batch estimation | 4. Forest plot | 5. Colour palette | 6. Realistic workflow | 7. Citation
Package: Ritable 0.1.0
Lucas França
Ritable: Pedigree-Based Heritability Estimation for Family Cohort Studies
Provides profile-likelihood variance-components estimation of narrow-sense heritability (h2) for quantitative traits in family cohort studies. Additive genetic relationship matrices are built from pedigrees via 'kinship2'. Phenotypes are inverse-normal transformed internally. Likelihood-ratio tests use a one-sided chi-squared boundary correction equivalent to SOLAR Eclipse. Ninety-five percent confidence intervals are derived from the profile likelihood rather than Wald approximations. Batch estimation over many traits returns tidy data frames ready for downstream visualisation (forest plots, heatmaps).
Authors:
Ritable_0.1.0.tar.gz
Ritable_0.1.0.zip(r-4.7)Ritable_0.1.0.zip(r-4.6)Ritable_0.1.0.zip(r-4.5)
Ritable_0.1.0.tgz(r-4.6-any)Ritable_0.1.0.tgz(r-4.5-any)
Ritable_0.1.0.tar.gz(r-4.7-any)Ritable_0.1.0.tar.gz(r-4.6-any)
Ritable_0.1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION |NEWS
card.svg |card.png
Ritable/json (API)
| # Install 'Ritable' in R: |
| install.packages('Ritable', repos = c('https://circadia-bio.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/circadia-bio/r-itable/issues
Pkgdown/docs site:https://r-itable.circadia-lab.uk
Last updated from:55f60f35e0 (on v0.1.0). Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-x86_64 | OK | 165 | ||
| source / vignettes | OK | 201 | ||
| linux-release-x86_64 | OK | 189 | ||
| macos-release-arm64 | OK | 97 | ||
| macos-oldrel-arm64 | OK | 122 | ||
| windows-devel | OK | 88 | ||
| windows-release | OK | 83 | ||
| windows-oldrel | OK | 88 | ||
| wasm-release | OK | 119 |
Exports:build_grmherit_batchherit_vcint_transformplot_forestRitable_colours
Dependencies:clievaluatehighrkinship2knitrlatticeMatrixquadprogrlangxfunyaml
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Build an additive genetic relationship matrix from a pedigree | build_grm |
| Batch heritability estimation over multiple traits | herit_batch |
| Profile-likelihood variance-components heritability estimation | herit_vc |
| Inverse-normal (rank-based) transformation | int_transform |
| Forest plot of heritability estimates | plot_forest |
| R-itable colour palette | Ritable_colours |
